Drug-Resistance Goes Traveling
07:34 PM ET 05/19/99
Study: Antibiotic Resistance Growing
Study: Antibiotic Resistance Growing
By BRIGITTE GREENBERG=
Associated Press Writer=
Jet-setting Americans who eat chicken and meat overseas are
bringing back resistance to certain antibiotics used to treat
stomach upset and other bacterial illnesses, according to a study.
The study, published in Thursday's New England Journal of
Medicine, is the first to link Americans' growing resistance to
antibiotics primarily to foreign travel. Until now, scientists
believed resistance was growing largely because doctors were
overprescribing antibiotics.
Resistance to the class of antibiotics called quinolones has
been reported in people in Europe and Asia because of the
widespread use of antibiotics in poultry and other livestock there,
but the problem had not been well-documented in the United States.
The study also attributed the problem in part to the growing use
of antibiotics in chickens in the United States. The Food and Drug
Administration approved the practice in 1995.
``There is definitely a public health problem with using
quinolones in poultry, and we need to take a hard look at that,''
said the study's lead author, Kirk E. Smith, an epidemiologist with
the Minnesota Health Department.
Smith said the study should prompt the FDA to adopt more
stringent guidelines for the use of antibiotics in food animals in
this country. But he said solving the problem ``is going to take a
very well-coordinated international effort.''
A spokesman for the Washington-based Animal Health Institute,
which represents producers of health products used in food animals,
said antibiotics are used sparingly on domestic livestock _ at most
3 percent of poultry _ and only when prescribed by a veterinarian.
What's more, he said, it's possible people are being exposed to
antibiotics through other means besides chicken while overseas,
like water, for example.
``What we don't know is the relative level of risk from
contaminated water, animal use, too many prescriptions. We need to
have some connection,'' said spokesman John Keeling.
Here's how researchers believe the problem goes from animals to
humans:
Chickens and other livestock are given antibiotics in feed and
drinking water to ward off infections and spur growth. A
corkscrew-shaped type of bacteria that normally lives in the
intestines of the animal becomes resistant to the antibiotics over
time.
Even after animals go to meat-processing plants, some meat can
remain contaminated with the resistant bacteria. Humans swallow the
bacteria if the meat is undercooked or contaminates other foods
during meal preparation.
The bacteria bring on gastroenteritis _ that is, diarrhea,
stomach cramps, fever and malaise. Doctors try to treat the illness
with antibiotics, but the bacteria have already built up
resistance, so it's tougher to get rid of.
The latest research examined 4,953 cases of bacterial infection
among Minnesota residents between 1992 and 1998. The scientists
found that the proportion of cases resistant to antibiotic
treatment increased from 1.3 percent in 1992 to 10.2 percent in
1998.
Patients answered a standardized survey that included questions
about antibiotic use, foods eaten, contact with animals and their
travels. The scientists attributed 75 percent of the cases to
foreign travel, especially to Mexico and especially in winter.
In an accompanying editorial, Henrik C. Wegener of the Danish
Zoonosis Center said physicians and veterinarians should be careful
not to overprescribe antibiotics.
``Increasing foreign travel and the internationalization of the
food trade make the use of antibiotics in food production a public
health issue of global dimensions,'' Wegener said.
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NutriTeam, Inc.

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